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Choice of detection methods
Detection using white light for imaging and picking, fluorescence for indicating expression levels.
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Detect recombinant proteins and expression markers
The protein construct contains epitope tag(s) e.g. His, FLAG® or Fc using tag-specific agents. |
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Label-free detection of antigen-specific mAbs from hybridomas
Fluorescently-conjugated or tagged antigen plus CIF (complex initiation factor) are used to generate precipitation. |
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Label-free detection of secreted antibodies
CloneDetect fluorescently- conjugated agents enable in situ detection of secreted mouse, rat or human IgG. These agents can be added as liquids or simply sprayed onto the colonies. Relative secretion levels are then measured across 1000’s of clones in parallel. |
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Imaging and analysis
Colonies are imaged in white light and fluorescence then analyzed by the system.
 White light imaging identifies and measures clone morphology, size and proximity
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Fluorescence imaging identifies levels of expression
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Ranking and data display
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Ranking plot
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Accurate picking and transfer
ClonePix selects colonies, transferring each colony into one well of a 96-well destination plate for growth assay and/or expansion of clonal cells.
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Brochures
ClonePix™ 2
Screening and selection of mammalian clones
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Accelerate Cell Line Development
ClonePix with CloneSelect Imager
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Recorded Webinars
Using high throughput automated selection to increase discovery of rare, high producing mammalian cell lines
Dr Dharshanan presents how the use of ClonePix has increased the probability of finding rare high producing clones at Inno Biologics.
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Optimal selection of monoclonal cell lines producing high amounts of biopharmaceutical human IgGs
Dr Gerritsen, Technology Expert, explains how Genmab have optimized and integrated emerging technologies to achieve an optimal, state-of-the-art process for generation of CHO cell lines expressing therapeutic IgGs.
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Listen now >
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